Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy

Small interfering RNA; principles, applications and challenges--

Gene silencing using RNAi (RNA interference), has recently been used as a successful laboratory technique in determining the function and control of gene expression and provides a wide range of applications in molecular biology and gene therapy. RNAi is a method of suppressing gene expression. In this direction, a single-stranded RNA molecule of about 21–23 nucleotides, called siRNA (small inte...

comparison of benefits from cardiac resynchronization therapy between patients with ischemic cardiomyopathy and patients with idiopathic dilated cardiomyopathy

background: cardiac resynchronization therapy (crt) is an effective treatment for patients with moderate to severe heart failure. however, 20-30% of patients remain non-responders to crt. we sought to identify which patients benefit the most from crt in regard to the etiology of heart failure. methods: eighty-three consecutive patients (62 men) who had a biventricular pacemaker inserted at tehr...

Mitral leaflet remodeling in dilated cardiomyopathy.

BACKGROUND Normal mammalian mitral leaflets have regional heterogeneity of biochemical composition, collagen fiber orientation, and geometric deformation. How leaflet shape and regional geometry are affected in dilated cardiomyopathy is unknown. METHODS AND RESULTS Nine sheep had 8 radio-opaque markers affixed to the mitral annulus (MA), 4 markers sewn on the central meridian of the anterior ...

Inflammation and Hyperreactivity in Mice Factor STAT6 Inhibits Allergic Airway Small Interfering RNA against Transcription

Small interfering RNA against ERK1/2 attenuates cigarette smoke-induced pulmonary vascular remodeling

Cigarette smoke may contribute to pulmonary vascular remodeling (PVR), a result of the proliferation of pulmonary artery smooth muscle cells (PASMCs), before pulmonary hypertension in chronic obstructive pulmonary disease (COPD). Activated extracellular signal-regulated kinases 1 and 2 (ERK1/2) are considered to be involved the process of PVR. This study investigated the potential role of ERK1/...